Choosing a Skeletal Muscle Relaxant
Less commonly, tachycardia, dysarthria, disorientation, and hallucinations have been reported . This is not a complete list of side effects and others may occur. Avoid taking MAO inhibitors (isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine) during treatment with this medication.
- It is ineffective in muscle spasm due to central nervous system disease.
- Along with its needed effects, a medicine may cause some unwanted effects.
- These include Modafinil, Armodafinil, Atazanavir, Donepezil, Dimenhydrinate, the Ipratropium nasal spray, and the Evening Primrose plant that is used in alternative medicine.
- If they’re more severe or don’t go away, talk with your doctor or pharmacist.
- There is also a case where the combination of a high concentration of Cyclobenzaprine and alcohol proved to be fatal.
- Do not flush medications down the toilet or pour them into a drain unless instructed to do so.
Acute recovery phase of myocardial infarction, and patients with arrhythmias, heart block or conduction disturbances, or congestive heart failure and hyperthyroidism. Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist.
Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include IBM Watson Micromedex (updated 3 Sep 2023), Cerner Multum™ (updated 28 Aug 2023), ASHP (updated 10 Aug 2023) and others.
Taking MAO inhibitors with this medication may cause a serious (possibly fatal) drug interaction. Avoid taking MAO inhibitors (isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine) during treatment with this medication. Most MAO inhibitors should also not be taken for two weeks before treatment with this medication.
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Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or are not alert and able to see well. This medicine is available only with your doctor’s prescription. Call your doctor if your symptoms do not improve after 3 weeks, or if they get worse. Older adults may be more sensitive to the effects of this medicine. It may not be safe to breast-feed while using this medicine.
Concomitant use of monoamine oxidase (MAO) inhibitors or within 14 days after their discontinuation. Hyperpyretic crisis seizures, and deaths have occurred in patients receiving cyclobenzaprine (or structurally similar tricyclic antidepressants) concomitantly with MAO inhibitor drugs. Cyclobenzaprine is a centrally acting skeletal muscle relaxant structurally related to tricyclic antidepressants. Cyclobenzaprine relieves skeletal muscle spasms of local origin without interfering with muscle function. In preclinical research, cyclobenzaprine reduced skeletal muscle hyperactivity.
After you eat the mixture, take a drink, and swish and swallow to make sure that you have received all the medication. Adding plans allows you to compare formulary status to other drugs in the same class. This medicine may cause some people to have blurred vision or to become drowsy, dizzy, or less alert than they are normally.
Cyclobenzaprine is best used in short-term treatment but may be used intermittently or long-term for chronic pain. A post-marketing surveillance program was carried out in 7607 patients with acute musculoskeletal disorders, and included 297 patients treated with FLEXERIL 10 mg for 30 days or longer. The overall effectiveness of FLEXERIL was similar to that observed in the double-blind controlled studies; the overall incidence of adverse effects was less (see ADVERSE REACTIONS). In case of acute cyclobenzaprine overdose, emergency medicine physicians and triage nurses should stabilize the patient. If EKG demonstrates QRS prolongation, the clinician should initiate sodium bicarbonate therapy. In severe overdose, ventricular arrhythmias and seizures may require MICU-level of care under the supervision of a critical care physician.
Check with your doctor before taking any of the above while you are using this medicine. Other drugs may interact with cyclobenzaprine, including prescription and over-the-counter medicines, how often should flexeril be taken vitamins, and herbal products. Although rare, deaths may occur from overdosage with FLEXERIL. Multiple drug ingestion (including alcohol) is common in deliberate cyclobenzaprine overdose.
If you notice any other effects, check with your healthcare professional. Take this medication by mouth with or without food as directed by your doctor. Do not increase your dose or use this drug more often or for longer than prescribed. Your condition will not improve any faster, and your risk of side effects will increase. Cyclobenzaprine caused slight to moderate increase in heart rate in animals. Cyclobenzaprine reduced or abolished skeletal muscle hyperactivity in several animal models.